ACU193
Our mission is to develop the right antibody for the right target and in the right amount – ultimately producing a more pronounced and clinically active treatment option for Alzheimer’s disease patients. Enter ACU193.
Our mission is to develop the right antibody for the right target and in the right amount – ultimately producing a more pronounced and clinically active treatment option for Alzheimer’s disease patients. Enter ACU193.
ACU193, our lead therapeutic candidate, is an anti-amyloid-beta oligomer (AβO) monoclonal antibody (mAb) with best-in-class potential for superior efficacy and safety in Alzheimer’s disease. It has been designed to have disease-modifying benefits with an improved safety profile, while also potentially providing symptomatic benefit for Alzheimer’s patients.
ACU193 is the first immunotherapy drug candidate to enter the clinic that was developed to target toxic AβOs: a persistent driver of Alzheimer’s-associated pathology and neurodegeneration. ACU193 addresses an underlying cause of Alzheimer’s by preventing toxic AβOs from binding to dendritic spines and helping preserve neuronal function. To learn more about AβOs, please visit our Science page.
ACU193 is the result of an eight-year research collaboration between Acumen and Merck, for which we hold its exclusive rights. Under the Acumen team’s stewardship, we further continued to profile in vivo activity and developability of ACU193. In 2017, the National Institute of Aging awarded a competitive $3.6 million U01 grant to Acumen for preclinical and early clinical development of ACU193.
In 2021, Acumen has initiated a first-in-human, Phase 1 clinical trial of ACU193 in early Alzheimer’s patients. We anticipate ACU193 to provide early-stage Alzheimer’s patients with clinically meaningful slowing of cognitive decline with an acceptable safety profile.